View Full Version : Easy morphine reaction?
hydroponichronic
2008-10-31, 22:41
There might not be anything here, but I figured it's worth asking. Can morphine be readily oxidzed to anything stronger or more bioavailable? IIRC, there's something to do with ClO- and Ni+ togeather in solution that selectively oxidizes 2nd alcohols to ketones, and while the one OH is on the aromatic ring, and can't go, the other might. Also, can anything simple be done when it comes to the double bond (the 7,8-didehydro bit)? Strong acid or some such?
how about di-acetylation...?
Not technically oxidation of course, but how much more potent than heroin do you want to go?!
hydroponichronic
2008-11-01, 05:09
how about di-acetylation...?
Not technically oxidation of course, but how much more potent than heroin do you want to go?!
I was hoping for something in the bleach and nickels range of OTC-ness. Not that I don't think I could whip up some AA if I really put my mind to it, I'd just rather have an easier route. I'm kind of a bum.
incorporated
2008-11-01, 14:32
Here you go. (http://panthrax.host.sk/heroin_make.html)
stateofhack
2008-11-01, 15:26
I was hoping for something in the bleach and nickels range of OTC-ness. Not that I don't think I could whip up some AA if I really put my mind to it, I'd just rather have an easier route. I'm kind of a bum.
If you have some glassware AA can be made with a little work :)
I'd imagine you could hydrogenate to give dihydromorphine (http://en.wikipedia.org/wiki/Dihydromorphine) which is apparently slightly stronger.
I'm sure you could fuck around and do some other shit (http://www.wipo.int/pctdb/en/wo.jsp?wo=1998046618) to that alkene handle - how much good it would do you is probably open to debate...
Alkenes can be surprisingly useful synthetic handles though....
I wonder if cyclopropanating at that position would yield anything interesting....
Von Bass
2008-11-01, 17:30
I'd imagine you could hydrogenate to give dihydromorphine (http://en.wikipedia.org/wiki/Dihydromorphine) which is apparently slightly stronger.
If you have enough, experiment with hydrogenation catalysts, heading straight to hydromorphone, which is quite strong. Sadly the patents used palladium or platinum based catalysts, which are rather expensive, but if a cheaper, more easily available catalyst could be found, it would be relatively easy.
about two weeks ago i saw a post that said platinum can be found on some type of battery for cars or trucks? could this be correct?
Well, I know the demethylation product of oxycodone, but haven't read any specific information about the oxidization reactions of morphine.
If you're careful, you might be able to present some interesting analytical data in a new characterization.
hydroponichronic
2008-11-02, 03:15
I've read that Nickel can be used as a hydrogenation catalyst, like Pt or Pd, but really inefficiently. There wouldn't happen to be a way to improve this efficiency, would there? Also, if hydrogenation was bypassed, and selective oxidation was the only thing done, is there any data about the ketone version of morphine? (oxymorphene?) My main concern is recreational value, but oral Bioavailability is also key.
If only there were more hours in the day...I'd have an easy OTC: MSG--->GHB, Robo syrup--->DXO, and now poppy seeds--->oxymorphane. But alas, I find myself sandwiched between too many AP classes, college apps, and a whole list of random other stuff. So the odds of me being able to run tests are slim to none.
stateofhack
2008-11-02, 13:26
I've read that Nickel can be used as a hydrogenation catalyst, like Pt or Pd, but really inefficiently. There wouldn't happen to be a way to improve this efficiency, would there? Also, if hydrogenation was bypassed, and selective oxidation was the only thing done, is there any data about the ketone version of morphine? (oxymorphene?) My main concern is recreational value, but oral Bioavailability is also key.
If only there were more hours in the day...I'd have an easy OTC: MSG--->GHB, Robo syrup--->DXO, and now poppy seeds--->oxymorphane. But alas, I find myself sandwiched between too many AP classes, college apps, and a whole list of random other stuff. So the odds of me being able to run tests are slim to none.
http://www.patentstorm.us/patents/4684735.html
http://en.wikipedia.org/wiki/Raney_nickel
this?
and now poppy seeds--->oxymorphane.
Y'know, I've heard something of differential solubility in diethyl ether, which means that with a little niacin, one could easily seperate out oxymorphone and morphine from morphine and codine...
...just sayin'.
hydroponichronic
2008-11-03, 11:03
http://www.patentstorm.us/patents/4684735.html
http://en.wikipedia.org/wiki/Raney_nickel
this?
Raney Nickel, eh? This might fall into my range as I happen to have a blast furnace at my disposal. Not so much a blast furnace as a barbecue grill on steroids, though.
And methylamine + 2CH2O--->trimethylamine? This is mentioned here: http://www.erowid.org/archive/rhodium/chemistry/methylamine.html
Is there an easier source of tertiary amine, or is this ^^^ about it?
It has also surprisingly been found that tertiary amines function as efficient promoting agents for different grades (types) of Raney Nickel catalyst. Thus, consistent hydrogenation of carbon-carbon double bonds can be achieved through the use of any Raney Nickel catalyst plus the promoting agent.
Looks promising. Now some selective oxidation might be employed and Schazaa! Hydromorphone!
EDIT: Would the fact that morphine contains a tertiary amine help this along? Possible to the point that no extra tert. amine would be needed?
blue_monday
2008-11-06, 05:31
about two weeks ago i saw a post that said platinum can be found on some type of battery for cars or trucks? could this be correct?
Idk if it's in car batteries but it's in catalytic converters in the exhaust system.http://en.wikipedia.org/wiki/Catalytic_converter#Technical_details
Someone could go to a junkyard with a sawzaw and collect a few, although i think most junkyards sell them off for their platinum content. But then there's also the trouble of how to identify which catalytic converters contain platinum, and how to extract the platinum.
DiamondX
2008-11-06, 11:24
Idk if it's in car batteries but it's in catalytic converters in the exhaust system.http://en.wikipedia.org/wiki/Catalytic_converter#Technical_details
Someone could go to a junkyard with a sawzaw and collect a few, although i think most junkyards sell them off for their platinum content. But then there's also the trouble of how to identify which catalytic converters contain platinum, and how to extract the platinum.
There is/was a tek on how to clean cat converter metals for other uses. I haven't seen it, but maybe someone else has it? I'm in college now, but where I grew up people would just dump their cars, so I was going to go and collect the converters, clean them, and either sell the metal or keep it for 'other stuff.' ;) I never got around to it, mainly because of work and not knowing if I would even be able to clean the metals.
stateofhack
2008-11-06, 21:42
There is/was a tek on how to clean cat converter metals for other uses. I haven't seen it, but maybe someone else has it? I'm in college now, but where I grew up people would just dump their cars, so I was going to go and collect the converters, clean them, and either sell the metal or keep it for 'other stuff.' ;) I never got around to it, mainly because of work and not knowing if I would even be able to clean the metals.
Seen it is on SM, too lazy to search for it now tho :(
DiamondX
2008-11-07, 05:03
Seen it is on SM, too lazy to search for it now tho :(
Don't bother, you already tried, remember? You're the one who told me about it... :mad:
hydroponichronic
2008-11-07, 06:45
Y'know, I've heard something of differential solubility in diethyl ether, which means that with a little niacin, one could easily seperate out oxymorphone and morphine from morphine and codine...
...just sayin'.
Somehow, I missed this post. WTF? Whatever. I have no solubility data on opiates & related compounds, and have had no luck searching, but I'll try something in the area of these keywords. This sounds really good.
On another note, my original idea of the ketone morphine is known as morphinone, and for some reason it took me forever to find it. Well, it's not worth a whole heck of a lot, not to mention I don't even know if my idea for OTC oxidation would work, so I'm going to leave that to someone else. I will try to do some research on OTC workable hydrogenation catalysts, but it'll take some time.
Aiight, so while I'm givin' this a bump, what is the current procedure for AA? Sodium Acetate + Acetyl Chloride? This looked good, but how to make acetyl chloride. Something to do with PCl3 (add WP and Cl2) and glacial acetic acid (how to do this? H2SO4 + Na(OAc)?). It's been a while since I slept so my research ability is impaired, and I can't seem to find a satisfactory write up for clandestine, food grade AA.
I will try to do some research on OTC workable hydrogenation catalysts, but it'll take some time.
Try (http://tinyurl.com/6dmwtt) google (http://tinyurl.com/6ofkx2) ;)
hahahaha i have 4 catalytic converters in my back yard they are worth like 40-100 dollars in scrap because of the platinum honey combs in them I also got copper wire,copper pipe,cast and aluminum im saving for scrap metal because IM HARDCORE and a few hundred bucks for drugs aint bad
stateofhack
2008-11-08, 11:37
Don't bother, you already tried, remember? You're the one who told me about it... :mad:
*Looks at empty bottles of alcohol*
"Me?....ah yeah!!!" :(