Kratom Info

[Bosli]

Cimetidine can cause gynomastia (bitch tits) in large doses, fyi. From experiments quinine and white grape fruit juice are best for opioid like compounds.

[Kingoffrogs]

What is Kratom?
The Kratom tree is a plant native to Southeast asia. The leaves of this plant contain psychoactive alkaloids such as Mitragynine and 7-hydroxymitragynine. The leaves are often chewed raw in southeast asia, but they can also be dried and crushed to make a powder. This powder can be ingested in a variety of ways, in pills, as a raw powder, or it can be brewed into a tea. Other edible kratom supplements include tinctures and gummies.

What are it's effects?
The effects of kratom are similar to DMX in that they rely on the amount of the dose administered. typically, a "low" dose produces stimulant effects (increased energy, alertness and rapid heart rate), while "high" doses typically produce sedative effects (relaxation, pain relief and confusion). The primary psychoactive compound in Kratom produces effects similar to morphine, as it is a partial opioid receptor antagonist. Depressant effects are also common at "high" doses. The effects of kratom can last anywhere from 2-8 hours, this, again, depends on the amount ingested.

NOTE
IMPORTANT: I am not a doctor. There is still much research to be done regarding kratom dosages and uses. I also could not find a reliable source that states MG/KG dosage of kratom. It is equally important to note that the chemical composition of kratom is not consistent between all kratom products.

Kratom Dosage Procedures
For beginners, a common dose is 1-3 grams. The effects produced at this dose are quite mild, and produce stimulant effects. A common mid-range dose is anywhere from 4-6 grams. At this dose, either highly stimulating effects can be achieved, or sedative effects can also be achieved. Side effects such as heavy perspiration may occur at this dose range. High doses typically range between 7-12 grams. At this dose, heavily sedating effects can set in, as well as other unpleasent side effects, such as nausea.

Side effects
The potential side effects of kratom are as follows:

Weight loss
Dry mouth
Chills, nausea and vomiting
Changes in urine and constipation
Liver damage
Dizziness
Drowsiness
Hallucinations and delusion
Depression and delusion
Breathing suppression
Seizure, coma and death
Muscle pain

NOTE: Many instances of reports where Kratom is reported to be the cause of death neglect the fact that, in almost all kratom overdose cases, other drugs (such as alchohol) were used in conjunction with kratom.

Best practices
As Kratom can lead to constipation/dehydration, it is best to stay hydrated while using kratom. Kratom also can be used successfully in conjunction with other drugs, it is not recommended as this can lead to unwanted side effects (including death). Certain supplements,

Speculative Effects
It is reported that kratom use in conjunction with so called "Kratom Potentiators" can perpetuate stronger effects from Kratom. Some of these potentiators include Caffeine, Grapefruit Juice, Chamomile tea, and cimetidine. There is some evidence that suggest some kratom potentiators actually do potentiate the effects of kratom, but there are also a great deal of anecdotes that back these claims. The potentiators I can find concrete evidence for are as follows:

These potentiators are proven to potentiate the effects of OPIODS IN GENERAL, NOT specifically kratom.

1: Cimetidine - Cimetidine may increase the effects of opioids by increasing their duration of action - https://pubmed.ncbi.nlm.nih.gov/8471...c%20metabolism.

2: Grape fruit juice (i'm not kidding) - https://americanaddictioncenters.org...s/potentiators

3: Alchohol (potentially dangerous) - Both alchohol and Kratom cause respiratory depression, therefore, the use of both simultaneously can be fatal. - https://americanaddictioncenters.org...mixing-opiates

4: Diazepam - https://americanaddictioncenters.org...s/potentiators